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This observation awaits propagated in vitro 6—8,—26. However, cells isolated from areas outside son and colleagues 22 reported that in five of the cancer of the hippocampus and subventricular zone require Kamagra soft Purchase Online patients they examined who received BrdU at between 15 levels of FGF-2 in order to give rise to neurons, rather than days and over 2 years early, all of them showed neurogenesis only glial cells 29.

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A variety of environmen- brain and spinal cord 9,27,28. FGF-2, however, is mem- tal, behavioral, genetic, neuroendocrine, and neurochemical ber of a family of 10 related, but genetically and functionally factors can regulate adult neurogenesis. Among those, only FGF-2 and FGF- cesses that lead to neurogenesis, cell proliferation and the 4 are mitogens for neural progenitor cells. Moreover, a com- subsequent differentiation and survival of newborn neurons, parison of amino acid sequences between the FGFs revealed can undergo differential regulation by these factors Table a striking similarity between a 10-amino acid sequence of 8.

This 10-amino acid sequence was been shown to elicit the mitogenic effects of FGF-2 and FGF-4 Genetics on neural progenitor cells, whereas similar regions in FGF- 1 and -5 were found to be inactive 35. In 1997 Kempermann and colleagues found that strains of Several factors have been found to be important for neu- mice differ with respect to rate of cell division and amount ronal differentiation in cultured progenitor cells. The phenotype and func- nied by a Kamagra soft Purchase Online increase in proliferation 18. Thus, strain tion that these cells acquire appears to be very much depen- differences not only influence the baseline rate of adult hip- dent on the specific environment into which they are trans- pocampal neurogenesis, but also influence how adult hippo- planted.

Indeed, proliferation, survival and tyrosine hydroxylase, and calbindin positive neurons in the differentiation of progenitor cells and their progeny are each olfactory bulb after grafting into the Kamagra soft Purchase Online migratory separately influenced by inheritable traits and are not uni- 112 Neuropsychopharmacology: Better understanding of their mechanisms of determination of stem and progenitor cells in the CNS 43. Intra- cerebroventricular infusion of EGF and FGF-2 in adult rats increased proliferation in the subventricular zone 44.

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